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Oligoasthenozoospermia is the main cause of male infertility， with complex and diverse causes. Currently， there are still some unclear causes of oligoasthenozoospermia in clinical practice， known as idiopathic oligoasthenozoospermia. With the development of high-throughput sequencing technology， it has been found that intestinal microbiota disorder may be an important promoting factor for the onset of oligoasthenozoospermia. Traditional Chinese medicine believes that "deficiency of kidney essence" is the core pathogenesis of oligoasthenozoospermia. In clinical practice， the method of tonifying the kidney and strengthening the essence has a significant therapeutic effect on oligoasthenozoospermia， but its mechanism of action has not been fully elucidated. Based on the basic theories of traditional Chinese medicine and molecular biology research， it has been found that there is a similarity between "kidney essence" and intestinal microbiota. During the onset of oligoasthenozoospermia， the disorder of intestinal microbiota has similarities with the pathogenesis of "deficiency of kidney essence" in traditional Chinese medicine. Moreover， traditional Chinese medicine for tonifying the kidney and strengthening the essence can regulate the disorder of intestinal microbiota， which may be one of the effective mechanisms for the treatment of oligoasthenozoospermia with the Bushen Yijing method. Based on this， this article explored the mechanism of Bushen Yijing method of traditional Chinese medicine in treating oligoasthenozoospermia from the perspective of intestinal microbiota， so as to provide new ideas for the treatment of oligoasthenozoospermia with traditional Chinese medicine.
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With the process of urbanization and population aging in China, the burden of cardiovascular disease and the incidence of coronary heart disease among postmenopausal women have greatly increased. Studies have found that the incidence of coronary heart disease in postmenopausal women is closely related to the level of estrogen, but there are still difficulties of low efficiency and large side effects in current therapies. Kidney deficiency has a strong correlation with reproductive development and overall function. The clinical manifestations and characteristics of postmenopausal coronary heart disease patients conform to the pathogenesis of kidney deficiency in traditional Chinese medicine. The kidney-invigorating method has a good efficacy in treating postmenopausal coronary heart disease patients. This paper summarizes clinical and pharmacological evidences, expounds the relationship between kidney deficiency and the level of estrogen, and the pathological mechanism of the kidney-tonifying method in the treatment of coronary heart disease, and defines the clinical efficacy and advantages of the kidney-tonifying method. The method may become an effective method to prevent and treat postmenopausal coronary heart disease, and is expected to benefit patients with coronary heart disease better.
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Female , Humans , China , Coronary Disease/drug therapy , Drugs, Chinese Herbal/therapeutic use , Estrogens , Kidney , Medicine, Chinese TraditionalABSTRACT
[Objective]The article summarizes the experience of Professor SUN Wei in treating nephritic hematuria.[Methods]The article discusses the clinical experience of Professor SUN Wei in the treatment on nephritic hematuria from the methods of learning from his daily treatment in inpatient and outpatient department,reading relative books and articles,recognition from the study of ancient classics,from etiology and pathogenesis,treatment,illustrating Professor's medication experience in the treatment of nephritic hematuria and with a case for evidence.[Results]Professor SUN Wei believes that the basic pathogenesis of nephritic hematuria is deficiency of the kidney with dampness heat and blood stasis,he creates the therapeutic modality of tonifying the kidney and promoting blood circulation and clearing away the damp-heat,he emphasizes reinforcing kidney and spleen, clearing heat and dampness,promoting blood circulation,conditioning the blood,he considers that the kidney Qi and Yin deficiency come first among kidney deficiency,long-term hematuria should not to be over-astringed.Professor SUN Wei is apt at the use of the herbs,all of these usually lead to good curative effect.[Conclusion]Professor SUN Wei's clinical experience in treating nephritic hematuria from tonifying the kidney and promoting blood circulation and clearing away the damp-heat is well worth extending in clinic for it always has significant effect.
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[Objective]To discuss the clinical experiences and unique views of Professor XIA Guicheng, a master of Chinese medicine in treating adenomyosis dysmenorrhea. [Method] To analyze the understanding of professor XIA Guicheng about the pathogenesis of adenomyosis dysmenorrhea. To sum up the clinical experiences in treating adenomyosis dysmenorrhea according to the kidney to adjust the cycle. [Result]For adenomyosis dysmenorrhea, XIA believes that the pathogenesis of this disease is the key virtual reality. The virtual refers to the deficiency of kidney-yang which is the root of its occurrence.The subject refers to the blood stasis which is its pathological basis. The deficiency of kidney-yang losses of warm effect, leading to stagnation of Qi and blood stasis for dysmenorrhea. According to the principle ofJi ze zhi biao,huan ze zhi ben, when the dysmenorrhea attacks severely, we should control the pain from the standard treatment, mainly including relieving spasm and pain ,warming Yang wet and tranquilizing mind. We ought to value the root cause in normal time, that is the kidney to adjust the cycle. In particular, we pay attention to the inter ovulation period of warming kidney to help Yang, and the patient's daily life, emotional diet. [Conclusion] Professor XIA Guicheng 's experience in treating adenomyosis dysmenorrhea is worth to spread.
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AIM:To treat the chemotherapy-induced premature ovarian failure ( POF) rats with the methods of tonifying kidney yin and yang by observing the indicator changes in apoptosis of ovarian granulosa cells and related cyto -kines before and after medication .METHODS:SD rats ( n=36) were chronically given intraperitoneal injection of cyclo-phosphamide ( CTX) for 15 d in order to establish the animal model of POF .The rats were randomly divided into control group, CTX group, CTX+kidney yin group and CTX +kidney yang group.The levels of tumor necrosis factor alpha (TNF-α) and interferon gamma ( IFN-γ) in the peripheral blood were detected by ELISA .The apoptosis of ovarian granulosa cells was observed by TUNEL method .The levels of apoptosis related proteins were determined by Western blot .RE-SULTS:After modeling , the levels of TNF-αand IFN-γin the peripheral blood were significantly increased .The protein expression of Bax was up-regulated and Bcl-2 was down-regulated .The apoptosis of ovarian granulosa cells was significantly induced with a deep staining .After treatment with tonifying kidney yin and yang , the levels of TNF-αand IFN-γin the pe-ripheral blood were decreased , the protein expression of Bax was down-regulated and Bcl-2 was up-regulated, and the apop-tosis of ovarian granulosa cells was reduced .CONCLUSION:The reserve function of the ovarian can be recovered by pre-scriptions of tonifying the kidney yin and yang via regulating the expression of TNF -α, IFN-γ, Bax and Bcl-2, and inhibi-ting the apoptosis of ovarian granulosa cells .
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Objective] To summarize teacher Qin’s clinical experience in treating premature ovarian failure by mainly reinforcing kidney. [Method] Collect the clinical cases, and analyze the etiology and pathogenesis, syndrome differentiation and treatment of premature ovarian failure for teacher Qin ’s. [Result] Teacher Qin thought that this disease was mainly due to kidney deficiency, especially kidney-yin deficiency, and accompanied by liver depression. This disease can be divided into kidney-yin deficiency, kidney-yang deficiency, deficiency of kidney-yin and yang, deficiency of kidney and liver depression. Reinforcing kidney-yin for kidney-yin deficiency; reinforcing kidney-yang for kidney-yang deficiency; reinforcing kidney-yin and yang for deficiency of kidney-yin and yang; tonifying the kidney essence and soothing liver-qi stagnation for deficiency of kidney and liver depression. [Conclusion] Treatment of premature ovarian failure is based on tonifying kidney, supplement on soothing liver, while some change therapies, should combine disease with syndrome.
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This paper was aimed to expound the concept , theoretical foundation , theoretical system as well as scientific connotation of the new therapeutic principle of tonifying the kidney to promote liver regeneration and repair . a brief introduction was provided for the development in both fundamental research and clinical appli-cations of liver disease treatment . It provided theoretical references for the clinical treatment of liver diseases .
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Objective To summary Jiangsu Province Hospital of TCM Professor Xia GuiCheng's experience on treatment of infertility by the method of Tonifying the Kidney and Regulating the Period of Menses(TKRPM), meanwhile to observe the clinic curative effect of TKRPM combined with clomiphene for infertility.Methods The patients were randomly recruited into a TCM group and a TCM combined western medicine group by digital randomized methed,30 cases in each group.The TCM treated group was treated by the method of TKRPM, while the other group was treated by TCM combined with clomiphene. Both groups were treated for three months.Syndromes, basal body temperature, results of B ultrasonic, and hormone in serum were observed. Results In TCM treated group , the clinic effective rate was 93.3%, the pregnant ratio was 33.3%, mean-cure-time for pregnant was(8.20±2.35)months; while in TCM combined western medicine group, the clinic effective rate was 100%, the pregnant ratio was 20%, and mean-cure-time for pregnant was (5.17±1.72) months.The clinic effective rates (U=0.358) and the pregnant ratios (x2=1.346) of two groups were not markedly difference (P＞0.05), but the mean-cure-time for pregnant of the two groups was markedly difference(P＜0.05). Conclusion TKRPM combined with induction drugs can cure infertility in a shorter time than using TCM only. Western medicine improves endocrine environment,while traditional Chinese medicine regulates the relationship among kidney, TianGui and the uterus fundamentally. The method will be more acceptable to patients.
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Objective To study the effects of tonifying kidney-yin on activities of embryo stem cell. Methods Embryonic stem cell line CRL-1825 was choosed as model cell in present study, and tonifying kidney-yin herb serum was added to CRL-1825 cell. The influence of tonifying kidney-yin on stem cell differentiation, cell cycle, apotosis and express of key genes were observed. Results Tonifying kidney-yin can inhibit stem cell differentiation and apotosis, promote stem cell proliferation and progression of cell cycle. In addition, tonifying kidney-yin can up-regulate Wnt, Oct4 gene expression, and down-regulation P16INK4a expression. Conclusions Tonifying kidney-yin can promote stem cell proliferation and maintain the state of stem cell.
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Objective To observe the effect of the therapy of tonifying the kidney on plasma NO and ET in dog with myocardial ischemia. Methods 20 dogs of myocarclial ischemia were divided into the model group control group, isosorbide mononitrate group and the therapy of tonifying the kidney group by random. The NO and ET of serum were measured before and after treatment. Results The level of NO was higher and the level of ET was lower than that of the isosorbide mononitrate group. There was significant difference between the control group and the therapy of tonifying the kidney group (P
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Objective To observe the influences on NO, NOS, ET of the Therapy of Tonifying the Kidney in patients with angina pectoris. Methods 50 patients with angina pectoris were treated by Chinese medicine of tonifying the kindey and the NO, NOS, ET, symptoms, ECG (ischemic ST-T changes), holter ECG, blood viscosity and blood fat were recorded. Results Obvious rise of NO, NOS and drop of ET. The improving of NO(?mol/L) from 46.42?7.94 to 70.16?12.94, NOS(u/mL) from 1.62?0.22 to 2.36?0.30, ET(pg/mL) from 64.46?15.12 to 41.42?8.76, the total efficacy of Chinese medicine of tomifying the kidney to improving of angina pectoris amounted to 92%, to improving of ECG amounted to 68%, the improving time (minutes) of holter ECG from 104.70?12.25 to 24.26?3.41. The rise of NO, NOS, the drop of ET and the therapeutic efficacy of Chinese medicine of tonifying the kidney are better than isosorbidi mononitratis with significant difference (P
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OBJECTIVE:To study the possible mechanism of Bushenshengsui I(BSSS I),a kind of compound Chinese herbs,in treatment of aplastic anaemiaMETHODS:The animal model of mice with aplastic anaemia was established by 60Co irradiationThe therapeutic effects of BSSS I on aplastic anaemia were observed with the changes of peripheral blood cell count,bone marrow GM-CFU-c and activities of blood IL-1,IL-2 and IL-6RESULTS:After treatment with BSSS I,the peripheral blood cell count,amount of bone marrow karyocyte and GM-CFU-c of bone marrow of the aplastic anaemia mice elevated markedly,and the blood IL-1 and IL-6 activities increased obviouslyThe levels of IL-6 increased to the level of normal and showed positive relationship with IL-1(r=0904)The levels of IL-2 of the treatment group showed a decrease but with no significant differencesCONCLUSION:The results showed that BSSS I may improve the function of hematopoiesis by elevating the peripheral blood cells and the amount of bone marrow karyocytes,accelerating GM-CFU-c of bone marrow,and through moderating the activities of IL-1,IL-2,IL-6
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Objective:To investigate effects of strengthening the spleen and tonifying the kidney and their combination before and after exercise on relative indexes of metabolism of glucose and amino acids.Methods:Strengthening the spleen alone,tonifying the kidney alone or their combination before and after exercise was given to the rat receiving 7-week gradually increasing load exercise on a running platform,and after quantitative load,contents of serum lactic acid,urea nitrogen,glucose,hepatic glycogen,muscle glycogen,hemoglobin,and malondialdehyde(MDA)in renal tissue and activity of superoxide dismulase(SOD)in the renal tissue were determined.Results:Strengthening the spleen before exercise increased hepatic and muscle glycogen contents,and tonifying the kidney before exercise increased muscle glycogen content,and strengthening the spleen combined with tonifying the kidney before and after exercise increased hemoglobin level,strengthening the spleen followed by tonifying the kidney before exercise decreased serum lactic acid and urea nitrogen levels,increased muscle glycogen content and SOD activity/MDA content ratio in the kidney.Conclusion:Strengthening the spleen and tonifying the kidney play a certain role in reducing motion-related fatigue,while strengthening the spleen followed by tonifying the kidney before exercise has the best results.
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Objective:To observe changes of sexual hormone level,score for Hamilton depression scale(HAMD) and clinical score for TCM symptoms after treatment of female depression with the principle of soothing the liver and relieving depression,and tonifying the kidney and relieving mental stress.Methods:Sixty cases of female patients of depression were randomly assigned to a treatment group(n=30) and a control group(n=30) according to age and condition of patients.Scores for HAMD and TCM symptoms before and after treatment were recorded and compared in both groups.Serum estradiol(E_2),progestin(P) and prolactin(PRL) levels were determined in the patients of depression and healthy persons.Results:Hormone levels were correlated with HAMD scores and 4 factors of HAMD,and after treatment with the method for soothing the liver and tonifying the kidney,serum E_2 increased (P
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Objective To study the effect and mechanism of strengthening the spleen and tonifying the kidney on the function and apoptosis of kidney in rats.Methods The 42 male SD rats were randomly divided into quiet control group,exhausted exercise group and strengthening the spleen and tonifying the kidney group.Twenty four hours after exhaustive exercise,the concentrations of blood urea nitrogen(BUN),serum creatinine and urinary protein were determined.The apoptosis in kidneys of rats was detected by TUNEL.The structure of kidney was observed in the HE stain.Results Comparing with the exhausted exercise group,the concen- trations of BUN,serum creatinine and apoptotic index were lower significantly(P
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Objective: To observe therapeutic effect of the method for tonifying the kidney and soothing the liver on impotence. Methods: 80 cases of impotence were randomly divided into a treatment group treated by Bushen Shugan Pills and a control group treated by Jingui Shenqi Pills. They were treated for 3 months and the International Erection Index Functional (IIEF-5)was determined at the end of 0,1,2,3 months after administration. Results:The total effective rate was 77. 5% in the treatment group and 52. 5% in the control group with a significant difference between the two groups (P
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Objective: To observe therapeutic effect of the method for regulating and tonifying the kidney and removing blood stasis and toxic substance on chronic renal failure. Methods: 111 cases were divided into treatment group of 71 cases and a control group of 40 cases. They were reslectively treated with Yishen Granules and Niaoduqing. Before and after treatment, blood creatinine (SCr), endogeneous creatinine clearance rate (Ccr), blood urea nitrogen (BUN). P. Ca, hemoglobin (Hb), 24-hour urine protein. total cholesterol (TC). triglyceride (TG). high density lipoprotein-cholesterol (HDL-C), low density lipoprtein-cholesterol (LDL-C). plasma endothelin (ET). calaitonin gene related peptide (CGRP) and tumor necrosis factor-? (TNF-?) were determined. Results: In the treatment group. 38 cases were markedly effective. 23 cases were effective and 10 cases were ineffective, with a total effective rate of 85. 91%. and in the control group 2 cases were markedly effective, 7 cases were effective. 11 cases were ineffective, with a total effective rate of 72. 5%. There was a significant differtence in the markedly effective rate between the two groups (P